Diverse macrophage populations contribute to distinct manifestations of human cutaneous graft-versus-host disease.
Johanna StroblLaura-Marie GailLaura KrecuShaista MadadLisa KleisslLuisa UnterluggauerAnna RedlKveta BrazdilovaSimona SaluzzoPhilipp WohlfarthHanna A KnausMargit MitterbauerWerner RabitschMuzlifah A HaniffaGeorg StaryPublished in: The British journal of dermatology (2023)
Overall, our data reveal a surprisingly dynamic role of MNPs after HSCT. Specific and time-resolved targeting to repolarize this cell subset may present a promising therapeutic strategy in combatting GvHD skin inflammation.
Keyphrases
- single cell
- endothelial cells
- oxidative stress
- adipose tissue
- cell therapy
- induced pluripotent stem cells
- genome wide
- cancer therapy
- soft tissue
- big data
- allogeneic hematopoietic stem cell transplantation
- stem cells
- gene expression
- hematopoietic stem cell
- machine learning
- drug delivery
- dna methylation
- mesenchymal stem cells
- acute lymphoblastic leukemia