Characterization of amorphous celecoxib mixed with plasticizing (TPGS) and anti-plasticizing (PVP) ingredients using Hot Melt Extrusion.

Darlene SantiagoAdlin MendozaZuleyka MoralesJavier Santos

Published in: Journal of pharmaceutical innovation (2019)

Low drug content combined with anti-plasticizing (PVP) amounts and relatively low plasticizing (TPGS) amounts yields an amorphous dispersion that is characterized with strong H-bonding due to efficient mixing using HME.

Keyphrases

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