Early fine motor impairment and behavioral dysfunction in (Thy-1)-h[A30P] alpha-synuclein mice.

Sara Ekmark-LewénVeronica LindströmAstrid GumucioElisabeth IhseAnish BeherePhilipp J KahleEva NordströmMaria ErikssonAnna ErlandssonJoakim BergströmMartin Ingelsson

Published in: Brain and behavior (2018)

Taken together, our results show that the (Thy-1)-h[A30P] alpha-synuclein transgenic mouse model displays early Parkinson's disease-related symptoms with a concomitant downregulation of the dopaminergic system. Thus, this should be an appropriate model to study early phenotypes of alpha-synucleinopathies.

Keyphrases

mouse model
oxidative stress
signaling pathway
type diabetes
adipose tissue
metabolic syndrome
sleep quality