Essential role of ryanodine receptor 2 phosphorylation in the effect of azumolene on ventricular arrhythmia vulnerability in a rabbit heart model.

Daoyuan SiMohammed Ali AzamPatrick F H LaiNima ZamiriGalina KichiginaJohn AstaStéphane MasséMahmoud M BokhariAndreu Porta-SánchezChristopher LabosHuan SunPing YangKumaraswamy Nanthakumar

Published in: Journal of cardiovascular electrophysiology (2018)

Ventricular refibrillation following LDVF was reduced by azumolene, which also improves calcium dynamics. RyR2 phosphorylation at Ser2808 is a prerequisite for the beneficial effects of azumolene.

Keyphrases

catheter ablation
heart failure
atrial fibrillation
left ventricular
protein kinase
climate change
binding protein