A missense variant Arg611Cys in LIPE which encodes hormone sensitive lipase decreases lipolysis and increases risk of type 2 diabetes in American Indians.

Yunhua L MullerJeff SutherlandAnup K NairCigdem KorogluSayuko KobesWilliam C KnowlerCristopher V Van Houtnull nullAlan R ShuldinerRobert L HansonClifton BogardusLeslie J Baier

Published in: Diabetes/metabolism research and reviews (2021)

The Arg611Cys variant causes a modest impairment in lipolysis, thereby affecting glucose homoeostasis and risk of T2D.

Keyphrases

adipose tissue
intellectual disability
blood glucose
insulin resistance
type diabetes
metabolic syndrome