PGC1α-Mediated Metabolic Reprogramming Drives the Stemness of Pancreatic Precursor Lesions.

Rama Krishna Nimmakayala Satyanarayana RachaganiRamakanth Chirravuri VenkataSaravanakumar MarimuthuPalanisamy NallasamyRaghupathy VengojiSubodh M LeleSatyanarayana RachaganiKavita MallyaMokenge P MalafaMoorthy P PonnusamySurinder K Batra

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

ADM/PanINs and IPMNs show specific stemness signatures with unique metabolisms. Inhibition of PGC1α using SR18292 diminishes the specific stemness by targeting FAO-independent and FAO-dependent OXPhos of ADM/PanINs and IPMNs, respectively.

Keyphrases

stem cells
epithelial mesenchymal transition
skeletal muscle
cancer stem cells
genome wide
signaling pathway
dna methylation
gene expression