Assessment and correction of macroscopic field variations in 2D spoiled gradient-echo sequences.

Substantial improvements in R 2 ∗ accuracy and myelin water fraction mapping coverage can be achieved using the proposed model if higher flip angles are required. In this context, we demonstrated that the phase along the slice profile and the polarity of the slice-selection gradient are essential for proper modeling of the gradient-echo signal in the presence of macroscopic field variations.