Whole transcriptome profiling of placental pathobiology in SARS-CoV-2 pregnancies identifies placental dysfunction signatures.
Nataly StylianouIsmail SebinaNicholas A MatigianJames H MonkmanHadeel DoehlerJoan RöhlMark C AllenbyAndy NamLiuliu PanAnja RockstrohHabib SadeghiradKimberly ChungThais SobanskiKen O'ByrneAna Clara Simoes Florido AlmeidaPatricia Zadorosnei RebutiniCleber Machado SouzaEmanuele Therezinha Schueda StonogaMajid Ebrahimi WarkianiCarlos SalomonKirsty R ShortLana McClementsAnna Flávia Ribeiro Dos Santos MiggiolaroRuby Yun-Ju HuangGabrielle T BelzFernando Souza-Fonseca GuimaraesVicki L CliftonChamindie PunyadeeraPublished in: Clinical & translational immunology (2024)
Our findings demonstrate the utility of spatially resolved transcriptomic analysis in defining the underlying pathogenic mechanisms of SARS-CoV-2 in pregnancy, particularly its role in placental dysfunction. Furthermore, this study highlights the significance of digital spatial profiling in mapping the intricate crosstalk between trophoblasts and villous core stromal cells, thus shedding light on pathways associated with placental dysfunction in pregnancies with SARS-CoV-2 infection.