Msh3 and Pms1 Set Neuronal CAG-repeat Migration Rate to Drive Selective Striatal and Cortical Pathogenesis in HD Mice.

Nan WangShasha ZhangPeter LangfelderLalini RamanathanMary PlascenciaFuying GaoRaymond VacaXiaofeng GuLinna DengLeonardo E DionisioBrinda C PrasadThomas VogtSteve HorvathJeffrey S AaronsonJim RosinskiXiangdong William Yang

Published in: bioRxiv : the preprint server for biology (2024)

Msh3 and Pms1 are genetic drivers of sequential striatal and cortical pathogenesis in Q140 mice by mediating selective CAG-repeat migration in HD vulnerable neurons.

Keyphrases

high fat diet induced
parkinson disease
functional connectivity
spinal cord
gene expression
wild type
skeletal muscle
spinal cord injury
deep brain stimulation