Evaluation of pharmacokinetic-pharmacodynamic relationships and selection of drug combinations for tuberculosis.
Morris MuliaditanOscar Della PasquaPublished in: British journal of clinical pharmacology (2020)
The use of a drug-disease modelling framework may provide a more robust rationale for extrapolation and selection of dose and companion drugs in humans. Our analysis demonstrates that RZ and BZ should be considered as a backbone therapy in prospective novel combination regimens against tuberculosis.