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Harm avoidance and childhood adversities in patients with obsessive-compulsive disorder and their unaffected first-degree relatives.

Katharina BeyL LennertzA RieselJ KlawohnC KaufmannS HeinzelR GrützmannN KathmannM Wagner
Published in: Acta psychiatrica Scandinavica (2017)
Our results provide further evidence for a diathesis-stress model of OCD. While patients and unaffected relatives share elevated levels of harm avoidance, supporting the role of harm avoidance as an endophenotype of OCD, a heightened severity of childhood adversity was only observed in patients. The assumed biological underpinnings of these findings are discussed.
Keyphrases
  • obsessive compulsive disorder
  • end stage renal disease
  • ejection fraction
  • chronic kidney disease
  • prognostic factors
  • peritoneal dialysis
  • deep brain stimulation