Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis.

Lin LeiAlix BruneauHaquima El MourabitJustine GuéganTrine FolseraasSara LemoinneTom Hemming KarlsenBénédicte HoareauRomain MorichonEster Gonzalez-SanchezClaire GoumardVlad RatziuPierre CharbordJérémie GautheronFrank TackeThierry JaffredoAxelle CadoretChantal Housset

Published in: Hepatology (Baltimore, Md.) (2022)

PMSCs form a small reservoir of expansive myofibroblasts, which, in interaction with neovessels and HSC-MFs that mainly arise through differentiation from a preexisting pool, underlie the formation of fibrotic septa in all types of liver diseases.

Keyphrases

liver fibrosis
mesenchymal stem cells
water quality
bone marrow
idiopathic pulmonary fibrosis
umbilical cord
extracellular matrix