Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease.

Preeti Lakshman KumarAva C WilsonAlison RoccoMichael H ChoEmily WanBrian D HobbsGeorge R WashkoVictor E OrtegaStephanie A ChristensonXingnan LiJ Michael WellsSurya P BhattDawn L DeMeoSharon M LutzHarry RossiterRichard CasaburiStephen I RennardDavid A LomasWassim W LabakiRuth Tal-SingerRussel P BowlerCraig P HershHemant K TiwariMark DransfieldAnna Thalacker-MercerDeborah A MeyersEdwin K SilvermanMerry-Lynn N McDonaldnull null

Published in: Journal of cachexia, sarcopenia and muscle (2021)

The EFNA2 and BAIAP2 genes were significantly associated with weight loss in COPD participants. Collectively, the integrative network analyses indicated genetic variation associated with weight loss in COPD may influence skeletal muscle regeneration and tissue remodelling.

Keyphrases

weight loss
skeletal muscle
bariatric surgery
roux en y gastric bypass
chronic obstructive pulmonary disease
stem cells
gastric bypass
genome wide
insulin resistance
lung function
bioinformatics analysis
genome wide identification
weight gain
metabolic syndrome
dna methylation
body mass index