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The impact of HLA-DRB1 alleles in a Hellenic, Pediatric-Onset Multiple Sclerosis cohort: Implications on clinical and neuroimaging profile.

Charalampos SkarlisNikolaos MarkoglouMaria GontikaArtemios ArtemiadisMaria-Roser PonsLeonidas StefanisMarinos DalakasGeorge ChrousosMaria C Anagnostouli
Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2024)
The HLA-DRB1*03 allele was associated with a higher risk for POMS, replicating our previous findings, and with a lower risk for brainstem lesion development, a common clinical and neuroimaging feature in POMS, while HLA-DRB1*07 and HLA-DRB1*11 display a protective role. These findings expand the existing knowledge of HLA associations and POMS.
Keyphrases
  • multiple sclerosis
  • healthcare
  • machine learning
  • deep learning
  • young adults
  • white matter