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Combined Photothermal and Ionizing Radiation Sensitization of Triple-Negative Breast Cancer Using Triangular Silver Nanoparticles.

James SearsJessica SwannerCale D FahrenholtzChristina SnyderMonica RohdeNicole Levi-PolyachenkoRavi Singh
Published in: International journal of nanomedicine (2021)
If given at a high enough dose, IR, heat, or TAgNPs alone could be sufficient for tumor treatment. However, when the dose of one or all of these modalities increases, off-target effects also increase. The challenge lies in identifying the minimal doses of each individual treatment such that when combined they provide maximum selectivity for treatment of TNBC cells with minimum off-target effects on non-malignant breast cells. Our results provide proof of concept that this combination is highly selective for TNBC cells while sparing non-malignant mammary epithelial cells. This treatment would be particularly important for patients undergoing breast conservation therapy and for treatment of invasive tumor margins near the periphery where each individual treatment might be at a sub-therapeutic level.
Keyphrases
  • patients undergoing
  • induced apoptosis
  • combination therapy
  • oxidative stress
  • photodynamic therapy
  • mesenchymal stem cells
  • cell therapy
  • cancer therapy
  • heat stress