Postnatal development of projections of the postrhinal cortex to the entorhinal cortex in the rat.

The ability to encode and retrieve contextual information is an inherent feature of episodic memory that starts to develop during childhood. The postrhinal cortex, an area of the parahippocampal region, has a crucial role in encoding object-space information and translating egocentric to allocentric representation of local space. The strong connectivity of POR with the adjacent entorhinal cortex, and consequently the hippocampus, suggests that the development of these connections could support the postnatal development of contextual memory. Here, we report that postrhinal cortex projections of the rat develop progressively from the first to the third postnatal week starting in the medial entorhinal cortex before spreading to the lateral entorhinal cortex. The increased spread and complexity of postrhinal axonal distributions is accompanied by an increased complexity of entorhinal dendritic trees and an increase of postrhinal - entorhinal synapses, which supports a gradual maturation in functional activity. SIGNIFICANCE STATEMENT Postrhinal-entorhinal cortical interplay mediates important aspects of encoding and retrieval of contextual information that is important for episodic memory. To better understand the function of the postrhinal interactions with the entorhinal cortex we studied the postnatal development of the connection between the two cortical areas. Our study describes the postnatal development of the postrhinal-to-entorhinal projections as established with neuroanatomical and electrophysiological methods. The projections gradually reach functionally different areas of the entorhinal cortex, reaching the area involved in spatial functions first, followed by the part involved in representing information about objects and sequences of events.