[18F]DPA-714 PET imaging shows immunomodulatory effect of intravenous administration of bone marrow stromal cells after transient focal ischemia.
Chengbo TanSongji ZhaoKei HigashikawaZifeng WangMasahito KawaboriTakeo AbumiyaNaoki NakayamaKen KazumataNaoyuki UkonHironobu YasuiNagara TamakiYuji KugeHideo ShichinoheKiyohiro HoukinPublished in: EJNMMI research (2018)
The present results suggest that BMSC therapy could be effective in ischemic stroke due to modulation of systemic inflammatory responses. The [18F]DPA-714 PET/CT system can accurately demonstrate brain inflammation and evaluate the BMSC therapeutic effect in an imaging context. It has great potential for clinical application.
Keyphrases
- pet ct
- pet imaging
- positron emission tomography
- bone marrow
- cerebral ischemia
- high resolution
- oxidative stress
- mesenchymal stem cells
- white matter
- high dose
- resting state
- computed tomography
- human health
- functional connectivity
- risk assessment
- brain injury
- mass spectrometry
- photodynamic therapy
- fluorescence imaging
- replacement therapy