Case reports of hypercalcemia and chronic renal disease due to cosmetic injections of polymethylmethacrylate (PMMA).
Arthur Gus ManfroMauricio LutzkyJosé Miguel S DoraMilton A S KalilRoberto Ceratti ManfroPublished in: Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia (2021)
Cosmetic injections of fillers are common plastic surgery procedures worldwide. Polymethylmethacrylate (PMMA) is a filler approved only for minimally invasive procedures in facial tissue and is among the most frequently used injectable substances for cosmetic purposes. Injection of a large volume of PMMA may lead to the development of severe hypercalcemia and chronic kidney damage in a probably underestimated frequency. In such cases, hypercalcemia develops due to a granulomatous foreign body reaction with extrarenal production of calcitriol. In the present report, we describe the cases of two patients who received injections of large volumes of PMMA and developed severe hypercalcemia and advanced chronic kidney disease. These reports highlight the importance of adhering to regulations regarding the use of PMMA and properly informing patients of the possibility of complications before undertaking such procedures.
Keyphrases
- end stage renal disease
- chronic kidney disease
- ultrasound guided
- hyaluronic acid
- minimally invasive
- platelet rich plasma
- peritoneal dialysis
- newly diagnosed
- early onset
- drug induced
- oxidative stress
- risk factors
- case report
- emergency department
- drinking water
- patient reported outcomes
- interstitial lung disease
- systemic sclerosis
- soft tissue
- tissue engineering