Applications of tert -butanesulfinamide in the synthesis of N-heterocycles via sulfinimines.

Chiral sulfinamides are among the best known chiral auxiliaries in the stereoselective synthesis of amines and their derivatives. The most extensively used enantiopure tert -butanesulfinamide emerged as the gold standard among many others over the last two decades. The present review attempts to provide an overview of tert -butanesulfinamide mediated asymmetric N-heterocycle synthesis via sulfinimines and covers literature from 2010-2020. This methodology offers general access to structurally diverse piperidines, pyrrolidines, azetidines, and their fused derivatives that represent the structural motif of many natural products and therapeutically applicable compounds.