Total adiponectin is inversely associated with platelet activation and CHA₂DS₂-VASc score in anticoagulated patients with atrial fibrillation.

Roberto CarnevaleDaniele PastoriMariangela PeruzziElena De FalcoIsotta ChimentiGiuseppe Biondi-ZoccaiErnesto GrecoAntonino G M MarulloCristina NocellaFrancesco VioliPasquale PignatelliCamilla CalvieriGiacomo Frati

Published in: Mediators of inflammation (2014)

AF patients at high risk of stroke disclose low and high levels of APN and sCD40L, respectively, suggesting a role for APN if it favors platelet activation in vivo in this clinical setting. Enhancing APN levels may be a future goal to reduce the risk of vascular outcomes in AF patients.

Keyphrases

atrial fibrillation
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
metabolic syndrome
prognostic factors
insulin resistance
adipose tissue
skeletal muscle