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Pinostrobin attenuates azoxymethane-induced colorectal cytotoxicity in rats through augmentation of apoptotic Bax/Bcl-2 proteins and antioxidants.

Bassam Ali Abed WahabNur Ain SalehenMahmood Ameen AbdullaAhmed A J JabbarIbrahim Abdel Aziz IbrahimGhassan AlmaimaniMustafa AbdulMonam ZainelGhazi A BamagousRiyad A AlmaimaniHussain A AlmasmoumMazen M GhaithWesam F FarrashYahya A Almutawif
Published in: SAGE open medicine (2023)
The chemoprotective efficiency of PN against azoxymethane-induced aberrant crypt foci is shown by lower aberrant crypt foci values and higher aberrant crypt foci inhibition percentage, possibly through augmentation of genes responsible for apoptotic cascade and inflammations originating from azoxymethane oxidative stress insults.
Keyphrases
  • diabetic rats
  • oxidative stress
  • cell death
  • high glucose
  • drug induced
  • anti inflammatory
  • induced apoptosis
  • genome wide
  • gene expression
  • soft tissue
  • endothelial cells
  • dna methylation
  • transcription factor