Impact of UCP2 depletion on heat stroke-induced mitochondrial function in human umbilical vein endothelial cells.

Wei HuangLiangfeng MaoWeidang XieSumin CaiQiaobing HuangYanan Liu Zhongqing Chen

Published in: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (2022)

Our results indicate that UCP2 protects against HS-induced vascular endothelial damage and that it enhances mitochondrial function. These findings reveal that UCP2 can be a potential contributor to mechanism-based therapeutic strategies for HS.

Keyphrases

high glucose
endothelial cells
diabetic rats
oxidative stress
drug induced
genome wide
risk assessment
gene expression
dna methylation
climate change
vascular endothelial growth factor