Polymeric engineering of AIEgens for NIR-II fluorescence imaging and detection of abdominal metastases of ovarian cancer in vivo .
Xiaobo ZhouYuhan ZengShijie LiKe ZhangLingfeng ZhaoGuo LiQi WangHaiwei JiMingmin WuJinxia LiuYuling QinWei FengFuyou LiLi WuPublished in: Journal of materials chemistry. B (2023)
A polymeric engineering design principle is proposed for the construction of small-sized (∼20 nm) NIR-II AIEgen-doped nanodots (AIEdots) with high brightness and prolonged circulation time in blood vessels. With the utilization of the as-designed NIR-II AIEdots, the successful achievement of high-resolution NIR-II fluorescence imaging of tumor vessels and precise detection of abdominal metastases of ovarian cancer has been attained.