Anti-Inflammatory Effects of GLP-1 Receptor Activation in the Brain in Neurodegenerative Diseases.
Yolanda Diz-ChavesZainab MastoorCarlos SpuchLucas C González-MatíasFederico MalloPublished in: International journal of molecular sciences (2022)
The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also produced in the brain and displays a critical role in neuroprotection and inflammation by activating the GLP-1 receptor signaling pathways. Several studies in vivo and in vitro using preclinical models of neurodegenerative diseases show that GLP-1R activation has anti-inflammatory properties. This review explores the molecular mechanistic action of GLP-1 RAS in relation to inflammation in the brain. These findings update our knowledge of the potential benefits of GLP-1RAS actions in reducing the inflammatory response. These molecules emerge as a potential therapeutic tool in treating neurodegenerative diseases and neuroinflammatory pathologies.
Keyphrases
- inflammatory response
- signaling pathway
- oxidative stress
- resting state
- white matter
- cerebral ischemia
- healthcare
- anti inflammatory
- functional connectivity
- lipopolysaccharide induced
- metabolic syndrome
- brain injury
- adipose tissue
- blood pressure
- insulin resistance
- weight loss
- epithelial mesenchymal transition
- cell proliferation