Human CASPR2 Antibodies Reversibly Alter Memory and the CASPR2 Protein Complex.

Bastien JoubertMar Petit-PedrolJesús PlanagumàFrancesco MannaraMarija RadosevicMaria MarsalEstibaliz MaudesAnna García-SerraEsther AguilarAlba Andrés-BilbéXavier GasullPablo Loza-AlvarezLidia SabaterMyrna R RosenfeldJosep Dalmau

Published in: Annals of neurology (2022)

IgG from patients with anti-CASPR2 encephalitis causes reversible memory impairment, inhibits the interaction of CASPR2/TAG1, and decreases the levels of CASPR2 and related proteins (VGKC, AMPAR). These findings fulfill the postulates of antibody-mediated disease and provide a biological basis for antibody-removing treatment approaches. ANN NEUROL 2022;91:801-813.

Keyphrases

endothelial cells
working memory
induced pluripotent stem cells
combination therapy
binding protein
small molecule
amino acid