Catalytic Enantioselective Synthesis of 2,5-Dihydrooxepines.
Su Yong ShimSoo Min ChoAnipireddy VenkateswarluDo Hyun RyuPublished in: Angewandte Chemie (International ed. in English) (2017)
A Michael addition initiated cyclopropanation/retro-Claisen rearrangement tandem reaction was developed for the enantioselective synthesis of highly functionalized 2,5-dihydrooxepines. In the presence of a chiral oxazaborolidinium ion (COBI) catalyst, the reaction proceeds to give good yields and high enantioselectivity.