Modulation of Aggregation-Caused Quenching to Aggregation-Induced Emission: Finding a Biocompatible Polymeric Theranostics Platform for Cancer Therapy.

Cheng WangZiyu WangShaoqing ChenPengfei CuiLin QiuShuwen ZhouHua JiangPengju JiangJianhao Wang

Published in: Macromolecular rapid communications (2021)

Dual intramolecular FRET polymers are synthesized via Suzuki coupling and their luminescence characteristics from aggregation-caused quenching (ACQ) to aggregation-induced emission (AIE) is modulated conveniently by adjusting the charged ratios. The finally obtained AIE polymer is further employed to construct doxorubicin loaded nanoparticles as a promising theranostics platform for cancer therapy.

Keyphrases

cancer therapy
energy transfer
drug delivery
fluorescent probe
living cells
quantum dots
high throughput
drug release
ionic liquid
solid state
room temperature
single molecule
single cell