Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type primary glioblastoma.

Yoonhee NamHarim KooYingxi YangSang ShinZhihan ZhuDonggeon KimHee Jin ChoQuanhua MuSeung Won ChoiJason K SaYun Jee SeoYejin KimKyoungmin LeeJeong-Woo OhYong-Jun KwonWoong-Yang ParkDoo-Sik KongHo Jun SeolJung-Il LeeChul-Kee ParkHye Won LeeYeup YoonJi-Guang Wang

Published in: Genome medicine (2023)

We identified molecular characteristics associated to TMZ sensitivity, and illustrate the potential clinical value of a ML model trained from pharmacogenomic profiling of patient-derived GSC against IDH-wt GBMs.

Keyphrases

wild type
single cell
low grade
squamous cell carcinoma
resistance training
locally advanced
radiation therapy
rectal cancer