IV and oral fosfomycin pharmacokinetics in neonates with suspected clinical sepsis.

Zoe KaneSilke GastineChristina ObieroPhoebe WilliamsSheila MurungaJohnstone ThitiriSally EllisErika CorreiaBorna NyaokeKarin KipperJohn van den AnkerMike SharlandJames A BerkleyJoseph F Standing

Published in: The Journal of antimicrobial chemotherapy (2021)

Through this analysis a population pharmacokinetic model has been developed that can be used alongside currently available pharmacodynamic targets to select a neonatal fosfomycin dose based on an infant's PMA, PNA and weight.

Keyphrases

urinary tract infection
gram negative
intensive care unit
body mass index
acute kidney injury
physical activity
pulmonary embolism
weight loss
septic shock
low birth weight
preterm birth