Dissociation between skin test reactivity and anti-aeroallergen IgE: Determinants among urban Brazilian children.

Neuza Maria Alcântara-NevesRafael V VeigaJoão C M PonteSérgio S da CunhaSilvia M SimõesÁlvaro A CruzMaria YazdanbakhshSheila M MatosThiago Magalhães SilvaCamila A FigueiredoLain C Pontes-de-CarvalhoLaura C RodriguesRosemeire L FiacconePhilip J CooperMaurício L Barreto

Published in: PloS one (2017)

A variety of factors were found to be associated with decreased frequency of SPT such as unhygienic living conditions, infections, total IgE, IgE response to glycosylated allergens and genetic polymorphisms, indicating that multiple mechanisms may be involved. Our data, showing that exposures to an unhygienic environment and childhood infections modulate immediate allergen skin test reactivity, provide support for the "hygiene hypothesis".

Keyphrases

soft tissue
wound healing
young adults
air pollution
electronic health record
big data
machine learning
data analysis