Grewia mollis Leaf Extracts and Fractions Demonstrated Good Inhibitory Activity on Pro-Inflammatory Enzymes and with Lower Cytotoxicity in vitro.
Adamu Imam IsaSalmon A AdebayoMohammad S Al-ShahraniPublished in: Journal of inflammation research (2020)
Organic extracts of the leaves of Grewia mollis contained bioactive molecules with potent action on COX-2 and 15-LOX. Targeted high-resolution high-performance liquid chromatographic (HPLC) methods have streamlined and enhanced bioactive compound isolation and purification process. This allows for the separation of undesirable compounds that could cause metabolic cytotoxicity in the plant extract mixtures. The method could be used to develop an alternative therapeutic strategy to manage pain associated with chronic inflammation where the use of NSAID is problematic.
Keyphrases
- simultaneous determination
- high resolution
- oxidative stress
- ionic liquid
- tandem mass spectrometry
- ms ms
- liquid chromatography
- chronic pain
- mass spectrometry
- anti inflammatory
- high performance liquid chromatography
- neuropathic pain
- cancer therapy
- solid phase extraction
- tissue engineering
- high speed
- spinal cord
- cell wall