Effects of neferine on retinal tissue in experimental diabetic rat model.

Mehmet Cevik Hamidu Hamisi Gobeka Orhan Aydemir

Published in: International ophthalmology (2022)

DM was associated with lower TAC, higher TOS and apoptotic cells, as well as VEGF and PCNA immunoreactivities in the retina. Neferine altered parameters other than PCNA in the opposite direction, demonstrating reductive effects on DM.

Keyphrases

diabetic retinopathy
induced apoptosis
cell death
cell cycle arrest
optic nerve
type diabetes
optical coherence tomography
vascular endothelial growth factor
glycemic control
endoplasmic reticulum stress
oxidative stress
signaling pathway
insulin resistance
pi k akt