The Na/K-ATPase α1/Src interaction regulates metabolic reserve and Western diet intolerance.

Laura C KutzXiaoyu CuiJeffrey X XieShreya T MukherjiKayleigh C TerrellMinqi HuangXiaoliang WangJiayan WangAdam J MartinMarco T PessoaLiquan CaiHua ZhuJudith A HeinyJoseph I ShapiroGustavo BlancoZijian XieSandrine V Pierre

Published in: Acta physiologica (Oxford, England) (2021)

These results suggest that NKA α1/Src regulatory function may be targeted in metabolic diseases. Because Src regulatory capability by NKA α1 is exclusive to endotherms, it may link the aerobic scope hypothesis of endothermy evolution to metabolic dysfunction.

Keyphrases

tyrosine kinase
transcription factor
physical activity
oxidative stress
weight loss
south africa
drug delivery