Longitudinal Associations Between Blood Biomarkers and White-Matter MRI in Sport-Related Concussion: A Study of the NCAA-DoD CARE Consortium.

Yu-Chien Wu Qiuting WenRhea ThukralHo-Ching YangJessica M GillSujuan GaoKathleen A LaneTimothy B MeierLarry D RiggenJaroslaw HarezlakChristopher C GizaJoshua GoldmanKevin M GuskiewiczJason P MihalikStephen M LaConteStefan M DumaSteven P BroglioAndrew J Saykin Thomas Walker McAllisterMichael A McCrea

Published in: Neurology (2023)

This prospective study using data from the CARE Consortium demonstrated that in the early phase of SRC, white-matter microstructural integrity detected by DTI neuroimaging was associated with elevated levels of blood-based biomarkers of traumatic brain injury. Total tau in the blood showed the strongest association with white-matter microstructural changes.

Keyphrases

white matter
multiple sclerosis
traumatic brain injury
healthcare
palliative care
quality improvement
pain management
affordable care act
electronic health record
machine learning
chronic pain
computed tomography
severe traumatic brain injury
data analysis