MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation.

Katrin BöttcherKrista RomboutsFrancesca SaffiotiDavide RoccarinaMatteo RosselliAndrew HallTuVinh LuongEmmanuel A TsochatzisDouglas ThorburnMassimo Pinzani

Published in: Hepatology (Baltimore, Md.) (2018)

Our data provide evidence that MAIT cells in AILD patients have evolved towards an exhausted, profibrogenic phenotype and can contribute to the development of HSC-mediated liver fibrosis. These findings reveal a cellular and molecular pathway for fibrosis development in AILD that could be exploited for antifibrotic therapy. (Hepatology 2018;68:172-186).

Keyphrases

liver fibrosis
induced apoptosis
cell cycle arrest
end stage renal disease
newly diagnosed
ejection fraction
endoplasmic reticulum stress
multiple sclerosis
prognostic factors
signaling pathway
stem cells
oxidative stress
genome wide
electronic health record
bone marrow
mesenchymal stem cells