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Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.

Kevin R BersellTao YangJonathan D MosleyAndrew M GlazerAndrew T HaleDmytro O KryshtalKyungsoo KimJeffrey D SteimleJonathan D BrownJoe-Elie SalemCourtney C CampbellCharles C HongQuinn S WellsAmanda N JohnsonLaura ShortMarcia A BlairElijah R BehrEvmorfia PetropoulouYalda JamshidiMark D BensonMichelle J KeyesDebby NgoRamachandran S VasanQiong YangRobert E GersztenChristian ShafferShan ParikhQuanhu ShenPrince J KannankerilIvan P MoskowitzJohn D YorkThomas J WangBjörn C KnollmannDan M Roden
Published in: Circulation (2022)
variant as a cause of BrS, but also reveal a new general transcriptional mechanism of arrhythmogenesis of enhanced late sodium current caused by reduced PDGF receptor-mediated PI3K signaling.
Keyphrases
  • gene expression
  • transcription factor
  • heat shock
  • left ventricular
  • genome wide
  • single cell
  • smooth muscle
  • case report
  • vascular smooth muscle cells
  • heart failure
  • oxidative stress
  • catheter ablation
  • atrial fibrillation