Measurement of CSF core Alzheimer disease biomarkers for routine clinical diagnosis: do fresh vs frozen samples differ?
Giovanni BellomoSamuela CataldiSilvia PaciottiFederico Paolini PaolettiDavide ChiasseriniLucilla ParnettiPublished in: Alzheimer's research & therapy (2020)
Small but significant differences have been found for Aβ40, Aβ42/Aβ40 ratio, p-tau, and t-tau in fresh vs frozen samples. Importantly, these differences did not imply a modification in the A/T/(N) classification system. In order to know if different cutoffs for fresh and frozen samples are required, larger, multi-center investigations are needed.