Apolipoprotein E gene variants shape the association between dietary fibre intake and cognitive decline risk in community-dwelling older adults.

Andrea Unión-Caballero Tomás MeroñoCristina Andrés-LacuevaNicole Hidalgo-LiberonaMontserrat RabassaStefania BandinelliLuigi FerrucciMassimiliano FedecostanteRaúl Zamora-RosAntonio Cherubini

Published in: Age and ageing (2023)

dietary fibre intake was not associated with cognitive decline amongst older adults for 15 years of follow-up. Nonetheless, older subjects with APOE-ɛ4 haplotype may benefit from higher fibre intakes based on the reduced risk for cognitive decline in this high-risk group.

Keyphrases

cognitive decline
mild cognitive impairment
physical activity
copy number
type diabetes
gene expression
adipose tissue
skeletal muscle
weight loss
genome wide identification
genome wide analysis