Melatonin mitigated methotrexate-induced hepatotoxicity through interrelated biological processes.

Noura AbdallahMaggie E AmerMaher A AmerMohamed Amr El-Missiry Ibrahim M El-Sherbiny

Published in: Molecular biology reports (2024)

In summary, MLT modulates liver function and structure by orchestrating linked processes, including redox balance, inflammatory response, suppression of caspase-3, and DNA damage.

Keyphrases

dna damage
inflammatory response
drug induced
oxidative stress
diabetic rats
high glucose
cell death
lipopolysaccharide induced
high dose
induced apoptosis
lps induced
toll like receptor
endothelial cells
immune response
signaling pathway
stress induced
electron transfer