Single-cell analysis of immune and stroma cell remodeling in clear cell renal cell carcinoma primary tumors and bone metastatic lesions.

Shenglin MeiAdele M AlchahinIoanna TseaYoumna KfouryTaghreed HirzNathan Elias JeffriesTing ZhaoYanxin XuHanyu ZhangHirak SarkarShulin WuAlexander O SubtelnyJohn Inge JohnsenYida ZhangKeyan SalariChin-Lee WuMark A RandolphDavid T ScaddenDouglas M DahlJohn ShinPeter V KharchenkoPhilip J SaylorDavid B SykesNinib Baryawno

Published in: Genome medicine (2024)

These results provide a comprehensive analysis of the bone marrow niche in the setting of human metastatic cancer and highlight potential therapeutic targets for both cell populations and communication channels.

Keyphrases

single cell
bone marrow
rna seq
small cell lung cancer
squamous cell carcinoma
cell therapy
endothelial cells
mesenchymal stem cells
papillary thyroid
bone mineral density
postmenopausal women
body composition
young adults
induced pluripotent stem cells
lymph node metastasis
childhood cancer