Informing Decision-making for Transected Margin Reresection in Intraductal Papillary Mucinous Neoplasm-derived PDAC: An International Multicenter Study.
Joseph R HabibIngmar F RompenBenedict Kinny-KösterBrady A CampbellPaul C M AndelGreg D SacksAdrian T BilleterHjalmar C van SantvoortLois A DaamenAmmar A JavedBeat P Müller-StichMarc G BesselinkMarkus W BüchlerJin HeChristopher L WolfgangI Quintus MolenaarMartin LoosPublished in: Annals of surgery (2024)
In IPMN-derived PDAC, normal epithelium or low-grade dysplasia at the neck have similar outcomes while pancreatic neck margins with high-grade dysplasia or invasive cancer are associated with poorer outcomes. Conversion of a high-risk to low-risk margin after intraoperative frozen section is associated with survival benefit and should be performed when feasible.