Alternations of gene expression in PI3K and AR pathways and DNA methylation features contribute to metastasis of prostate cancer.

Yue ZhaoXin HuHaoran YuXin LiuHuimin SunChen Shao

Published in: Cellular and molecular life sciences : CMLS (2022)

PCa classification specific to AR and PI3K pathways provides novel biological insight into previously established PCa subtypes and may help develop personalized therapies. Our results support the potential clinical utility of DNA methylation signatures to distinguish tumor metastasis and to predict prognosis and outcomes.

Keyphrases

dna methylation
gene expression
genome wide
prostate cancer
radical prostatectomy
machine learning
deep learning
copy number
type diabetes
adipose tissue
weight loss
glycemic control