Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms.
Tiffany Y Wences ChirinoEdgar Rangel-LópezAlexandra Luna AnguloPaul Carrillo MoraCarlos Landa SolisMaría Alejandra Samudio CruzAlim C Fuentes BelloRogelio Paniagua PérezJuan Ríos MartínezLaura Sánchez ChapulPublished in: Pharmaceuticals (Basel, Switzerland) (2023)
The kynurenine pathway (KP) and the endocannabinoid system (ECS) are known to be deregulated in depression and obesity; however, it has been recognized that acute physical exercise has an important modulating role inducing changes in the mobilization of their respective metabolites-endocannabinoids (eCBs) and kynurenines (KYNs)-which overlap at some points, acting as important antidepressant, anti-nociceptive, anti-inflammatory, and antioxidant biomarkers. Therefore, the aim of this review is to analyze and discuss some recently performed studies to investigate the potential interactions between both systems, particularly those related to exercise-derived endocannabinoidome and kynurenine mechanisms, and to elucidate how prescription of physical exercise could represent a new approach for the clinical management of these two conditions.
Keyphrases
- anti inflammatory
- insulin resistance
- metabolic syndrome
- weight loss
- sleep quality
- high intensity
- type diabetes
- depressive symptoms
- high fat diet induced
- physical activity
- weight gain
- major depressive disorder
- ms ms
- oxidative stress
- resistance training
- human health
- drug induced
- respiratory failure
- neuropathic pain
- signaling pathway
- spinal cord injury
- bipolar disorder
- intensive care unit
- skeletal muscle
- spinal cord