MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway.

Te-Hsuan JangWei-Chieh HuangShiao-Lin TungSheng-Chieh LinPo-Ming ChenChun-Yu ChoYa-Yu YangTzu-Chen YenGuo-Hsuen LoShuang-En ChuangLu-Hai Wang

Published in: Journal of biomedical science (2022)

A novel miRNA-485-5p/KRT17/integrin/FAK/Src/ERK/β-catenin signaling pathway is unveiled to modulate OSCC cancer stemness and drug resistance to the common first-line chemotherapeutics. This provides a potential new therapeutic strategy to inhibit OSCC stem cells and counter chemoresistance.

Keyphrases

stem cells
cell migration
signaling pathway
tyrosine kinase
pi k akt
cancer stem cells
papillary thyroid
cell proliferation
epithelial mesenchymal transition
squamous cell
cell adhesion
cell therapy
squamous cell carcinoma
lymph node metastasis
human health
climate change
bone marrow