Icariside I reduces breast cancer proliferation, apoptosis, invasion, and metastasis probably through inhibiting IL-6/STAT3 signaling pathway.

Manting HouHui LiTingting HeSiwen HuiWenzhang DaiXiaorong HouJing ZhaoJia ZhaoJincai WenWen KanXiaohe XiaoXiaoyan ZhanZhaofang Bai

Published in: The Journal of pharmacy and pharmacology (2023)

These findings suggest that ICS I can inhibit breast cancer proliferation, apoptosis, invasion and metastasis probably via targeting IL-6/STAT3 pathway. Therefore, ICS I has the potential to become an innovative therapeutic candidate to breast cancer prevention and treatment.

Keyphrases

signaling pathway
pi k akt
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
cell proliferation
cell death
cell migration
epithelial mesenchymal transition
breast cancer risk
young adults
climate change
smoking cessation