The skeletal muscles of mice infected with Plasmodium berghei and Plasmodium chabaudi reveal a crosstalk between lipid mediators and gene expression.
Mauro Toledo MarrelliZhiying WangJian HuangMarco BrottoPublished in: Malaria journal (2020)
The results provide new insights into the molecular mechanisms of malaria-induced muscle damage and revealed a potential mechanism modulating inflammation in malarial muscles. These pre-clinical studies should help with future clinical studies in humans aimed at monitoring of disease progression and development of specific interventions for the prevention and mitigation of long-term chronic effects on skeletal muscle function.
Keyphrases
- plasmodium falciparum
- skeletal muscle
- gene expression
- oxidative stress
- diabetic rats
- single cell
- insulin resistance
- high glucose
- climate change
- dna methylation
- drug induced
- high fat diet induced
- genome wide
- physical activity
- current status
- signaling pathway
- human health
- metabolic syndrome
- type diabetes
- adipose tissue
- endothelial cells
- wild type