An ultrasound activated cyanine-rhenium(I) complex for sonodynamic and gas synergistic therapy.

Jiayi ZhuAi OuyangJiaqi HeJuan XieSamya Banerjee Qian-Ling Zhang Pingyu Zhang

Published in: Chemical communications (Cambridge, England) (2022)

A novel cyanine-rhenium(I) tricarbonyl complex is developed as a potent sonosensitizer and sono-activatable CO-releasing agent for synergistic sonodynamic therapy and CO gas therapy of cancer. The complex induced ferroptosis as the mode of cell death.

Keyphrases

cell death
magnetic resonance imaging
squamous cell carcinoma
room temperature
cancer therapy
computed tomography
oxidative stress
papillary thyroid
drug delivery
diabetic rats
cell proliferation
anti inflammatory
ultrasound guided
ionic liquid
contrast enhanced ultrasound