Role of endothelial Raptor in abnormal arteriogenesis after lower limb ischaemia in type 2 diabetes.

Ting LiuJiachen ZhangFangyuan ChangMengyu SunJinlong He Ding Ai

Published in: Cardiovascular research (2024)

Collectively, our study demonstrated the crucial role of endothelial Raptor in promoting ischaemia-induced arteriogenesis in T2DM by mediating VEGFR2 signalling. Thus, endothelial Raptor is a novel therapeutic target for promoting arteriogenesis and ameliorating perfusion in T2DM.

Keyphrases

lower limb
endothelial cells
type diabetes
glycemic control
high glucose
cardiovascular disease
diabetic rats
vascular endothelial growth factor
insulin resistance
computed tomography
skeletal muscle
oxidative stress