Revealing molecular architecture of FLT3 internal tandem duplication: Development and clinical validation of a web-based application to generate accurate nomenclature.

Yi DingGeoffrey Hughes SmithKristin DeebThomas SchneiderAndrew CampbellLinsheng Zhang

Published in: International journal of laboratory hematology (2022)

The web application generates accurate FLT3-ITD nomenclature from NGS results except in rare situations. The HGVS nomenclatures provide information on the molecular architecture of FLT3-ITDs and reveal details of complex insertions with partial duplications.

Keyphrases

acute myeloid leukemia
tyrosine kinase
high resolution
single molecule
genome wide
healthcare
gene expression
social media