Extrapolating Antifungal Animal Data to Humans - Is it reliable?
Victoria M StevensScott W MuellerPaul M ReynoldsRobert MacLarenTyree Heath KiserPublished in: Current fungal infection reports (2020)
Animal models have been a staple in the development and optimization of antifungal agents. They afford the ability to investigate uncommon diseases, such as invasive fungal infections, that would otherwise take years and many resources to complete. Although there are many benefits of animal models there are also shortcomings. This is why the reliability of extrapolating data from animal models to humans is often scrutinized.